Sodium Acetate → HCID 21933600, compound

HRID 1241235Notes

Reaction equation

HRID 1241235 reaction equation
Cl[O-].[Na+].[CH2:4]([C:7]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:8]=1[CH:9]=[N:10][OH:11])[CH:5]=[CH2:6].C([O-])(=O)C.[Na+]>C(Cl)Cl>[Cl:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:7]2[C:8]=1[C:9]1=[N:10][O:11][CH2:6][CH:5]1[CH2:4]2

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 23665760Sodium HypochloriteHCID 86614460HCID 86614460, compound

Product 1

HCID 21933600HCID 21933600, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At room temperature, 37.0 ml of a sodium hypochlorite solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution. The organic phase was dried and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno-[1,2-c]isoxazole in the form of a viscous oil.

Workup

  1. customthe organic phase was separated off
  2. extractionthe aqueous phase was extracted with methylene chloride
  3. washthe combined organic phases were washed with saturated ammonium chloride solution
  4. customThe organic phase was dried
  5. customthe solvent was removed

Sources & evidence

ORD record
ord-f2a854a2dccc4c8ea683dc4ad1278f5f
Source dataset
uspto-grants-2006_10
Patent number
US07115545B1

Reaction notes

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