HCID 21933594, compound → HCID 21933604, compound

HRID 1241240Notes

Reaction equation

HRID 1241240 reaction equation
O[C:2]([CH2:4][CH2:5][S:6][C:7]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10])=[O:3]>O>[Cl:17][C:15]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]2[C:16]=1[C:2](=[O:3])[CH2:4][CH2:5][S:6]2

Participants

3

Reactant 1

HCID 21933594HCID 21933594, compound

Product 1

HCID 21933604HCID 21933604, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

At 70° C., 50 g (0.18 mol) of methyl 2-(2-hydroxycarbonyleth-1-yl)thio-4-chlorobenzoate were added to 500 g of polyphosphoric acid, and the mixture was stirred for a further 30 minutes. The reaction mixture was then stirred into water and the resulting precipitate was filtered off with suction and dried. This gave 41.1 g (88%) of methyl 5-chloro-4-oxothiochromane-8-carboxylate.

Workup

  1. filtrationthe resulting precipitate was filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-de0dd34a101f4389ae179446f4175aef
Source dataset
uspto-grants-2006_10
Patent number
US07115545B1

Reaction notes

Loading…