HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1241337Generated: October 26, 2026
3-Chloroaniline → (3-Chlorophenyl)-(2-fluoro-9-isopropyl-9H-purin-6-yl)amine
https://huagongshe.com/reaction/1241337
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-Chloro-2-fluoro-9-isopropyl-9H-purine | HCID 11287361 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | (3-Chlorophenyl)-(2-fluoro-9-isopropyl-9H-purin-6-yl)amine | HCID 12084803 | 48.4% |
Reaction Steps
6-Chloro-2-fluoro-9-isopropyl-9H-purine (214 mg, 1 mmol) was mixed with 3-chloroaniline (127.6 mg, 1 mmol) in 12 mL n-BuOH. DIEA (357.6 mg, 2.8 mmol) was added and the solution was heated at 90° C. overnight. Solvent was removed in vacuo and the residue was chromatographed on silica gel (CH2Cl2/EtOAc 2:2, Rf 0.44) to get the product as a white solid (148 mg, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07115589B2 |
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| Source dataset | uspto-grants-2006_10 |
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| ORD ID | ord-56d88a99118a4df790fc467b97294f7d |
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| Source note | uspto-grants-2006_10 |
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