HCID 86585274, compound → HCID 21933779, compound

HRID 1241350Notes

Reaction equation

HRID 1241350 reaction equation
[CH2:1]([O:3][P:4]([C:9](=[C:18]1[CH:23]=[CH:22][C:21]([NH:24]C(=O)C(F)(F)F)=[CH:20][CH2:19]1)[P:10]([O:15][CH2:16][CH3:17])([O:12][CH2:13][CH3:14])=[O:11])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]>[OH-].[Na+]>[CH2:13]([O:12][P:10]([C:9]([P:4]([O:6][CH2:7][CH3:8])([O:3][CH2:1][CH3:2])=[O:5])=[C:18]1[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH2:23]1)([O:15][CH2:16][CH3:17])=[O:11])[CH3:14]

Participants

3

Reactant 1

HCID 86585274HCID 86585274, compound

Product 1

HCID 21933779HCID 21933779, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The above 1-(Bis-diethylphosphonomethylene-4-(N-trifluoroacetylamino)benzene (1.2 g, 2.52 mmols) in NaOH solution (0.1 N, 10 mL) was heated to 60_C for 5 h. The reaction mixture was cooled to rt, and extracted with methylene chloride. Combined organic layers were dried over sodium sulfate and concentrated to afford the product (0.85 g, 97%). MS: 412 (M+23).

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialCombined organic layers were dried over sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-eebf5be2ebf749cb82e332f1f7b35fdc
Source dataset
uspto-grants-2006_10
Patent number
US07115589B2

Reaction notes

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