反应详情

A solution of 5.00 g (38.42 mmol) of 1-(2-hydroxyethyl)imidazolidin-2-one 44-1 and 3.82 mL (52.39 mmol) of thionyl chloride in 75 mL of chloroform was stirred at reflux for 4 hours. The reaction was concentrated in vacuo to an orange oil, which was redissolved in chloroform and washed twice with water. The organic layer was dried and reconcentrated to give the crude desired product as an orange solid. The solid was used as obtained from the reaction without further purification.

1. temperatureat reflux for 4 hours
2. concentrationThe reaction was concentrated in vacuo to an orange oil, which
3. dissolutionwas redissolved in chloroform
4. washwashed twice with water
5. customThe organic layer was dried