反应详情

45-4 (0.10 g, 0.30 mmol) was dissolved in 10 mL of absolute ethanol. To this solution was added 10% Pd/C catalyst. This was then hydrogenolyzed for 7 hours at 60 psi. The catalyst was then filtered off and the filtrate was evaporated to an oil and flushed with methanol to afford 45-5. 1H-NMR (CD3OD): 3.62(m, 2H); 3.49(m, 2H); 3.24(t, 4H); 3.14(m, 1H); 3.03(m, 1H); 2.82(m, 2H); 2.72(complex, 4H); 2.20(m, 1H); 1.86(m, 1H).

1. filtrationThe catalyst was then filtered off
2. customthe filtrate was evaporated to an oil
3. customflushed with methanol
4. customto afford 45-5