Oxalyl chloride → HCID 21934531, compound

Participants

Reaction Conditions

Reaction Steps

3-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]-5-ethoxy-5-oxopentanoic acid (9.68 mmol) was dissolved in CH2Cl2 (10 mL) and cooled to 0° C. Oxalyl Chloride (2.0M in CH2Cl2; 25 mL) was added slowly. One drop of DMF was added to the reaction mixture. The reaction was warmed to room temperature and stirred for 18 hours. The reaction was concentrated in vacuo to give the crude product.

Provenance & Evidence