1,4-Dioxane → HCID 21934519, compound

Participants

Reaction Conditions

Reaction Steps

thyl 6-chloro-3-[2-(4-chlorophenyl)-1,3-thiazol-5-yl]-5-oxohexanoate, Scheme 2, Example A, (230 mg, 0.595 mmol) and 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanethioamide, Scheme 3, Step 1, (140 mg, 0.595 mmol) was dissolved in 1,4-dioxane (5 mL) and heated to 120° C. for 18 hours. The solvent was removed and the residue purified via reverse phase HPLC to give the product (180 mg, 44%). 1H NMR (DMSO-d6) δ1.10 (t, 3H), 1.77–1.85 (m, 2H), 2.02–2.11 (m, 2H), 2.68–2.90 (m, 6H), 2.95–3.18 (m, 4H), 3.38–3.46 (m, 2H), 3.86–3.95 (m, 2H), 4.00 (q, 2H), 6.55 (d, 1H), 7.18 (s, 1H), 7.48–7.55 (m, 2H), 7.57 (d, 1H), 7.62 (s, 1H), 7.80–7.85 (m, 2H).

Provenance & Evidence