HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86595789, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4-(Morpholin-4-yl)pyridin-2-amine | HCID 21934537 | — |
| Reactant | HCID 86595788 | HCID 86595788 | — |
| Product | HCID 86595789 | HCID 86595789 | — |
Reaction Steps
Dissolve (3S)-Ethyl 3-(1,3-benzodioxol-5-yl)-4-[2-(4-oxobutyl)-1,3-thiazol-4-yl]butanoate (230 mg, 0.6 mmol) and 4-morpholin-4-ylpyridin-2-amine (88 mg, 0.5 mmol) prepared according to Scheme 6, Example 1, in CH2Cl2. Add 3 mL THF and add NaBH(OAc)3. Stir at room temperature for 18 hours. Add 1.0 eq NaBH(OAc)3 and stir 24 hrs. The reaction was concentrated in vacuo and purified via reverse phase HPLC using a gradient of 10–60% CH3CN/H2O/0.5% HCl over 30 minutes to obtain the crude desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115596B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-03a1df963e514719a66a7cb809f25ad0 |
| Source note | uspto-grants-2006_10 |