HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 69588611, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4-(Morpholin-4-yl)pyridin-2-amine | HCID 21934537 | — |
| Reactant | HCID 21934557 | HCID 21934557 | — |
| Product | HCID 69588611 | HCID 69588611 | — |
Reaction Steps
Dissolve ethyl 3-(6-methoxypyridin-3-yl)-4-[2-(4-oxobutyl)-1,3-thiazol-4-yl]butanoate (374mg, 1.0 mmol) and 4-morpholin-4-ylpyridin-2-amine (150 mg, 0.836 mmol) prepared according to Scheme 6, Example 1, in CH2Cl2. Add NaBH(OAc)3 (251 mg, 1.12 mmol) and stir at room temperature for 18 hours. The reaction was concentrated in vacuo and purified via reverse phase HPLC using a gradient of 10–60% CH3CN/H2O/0.5% HCl over 30 minutes to obtain the crude desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115596B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b349c9cb361a4abbbbb8e173fa6df7ce |
| Source note | uspto-grants-2006_10 |