Ammonium formate → HCID 12041006, compound

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Reaction Steps

Alternatively, 5-(1,1-dioxido-2-isothiazolidinyl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinylamine (example 2) was prepared from 6-chloro-5(1,1-dioxido-2-isothiazolidinyl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3yl]-4-pyrimidineamine (0.040 mg, 0.084 mmol) from example 1, which was dissolved in MeOH (4 ml) and to which Pd/C (10%, 0.009 g) and ammonium formate (0.053 mg, 0.84 mmol, 10 equivalents) were added. The mixture was heated under reflux for 2 days and then allowed to cool to room temperature, before the catalyst was filtered off. The crude product was concentrated in vacuo.

Provenance & Evidence