4-Tert-butylcyclohexanecarbonyl chloride → 4-tert-butyl-N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

HRID 1241493Notes

Reaction equation

HRID 1241493 reaction equation
[NH2:1][CH:2]([C:5]1[C:6](=[O:14])[NH:7][C:8]([CH:11]2[CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[C:15]([CH:19]1[CH2:24][CH2:23][CH:22]([C:25](Cl)=[O:26])[CH2:21][CH2:20]1)([CH3:18])([CH3:17])[CH3:16]>>[C:15]([CH:19]1[CH2:20][CH2:21][CH:22]([C:25]([NH:1][CH:2]([C:5]2[C:6](=[O:14])[NH:7][C:8]([CH:11]3[CH2:13][CH2:12]3)=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:26])[CH2:23][CH2:24]1)([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 27572694-Tert-butylcyclohexanecarbonyl chlorideHCID 1355940716-(1-Aminopropyl)-3-cyclopropyl-1,2,4-triazin-5(4h)-one

Product 1

HCID 1355940774-tert-butyl-N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclohexanecarboxamide

Procedure

In analogy to the procedure for Example 36A, 250 mg (1.29 mmol) 6-(1-aminopropyl)-3-cyclopropyl-1.2,4-triazin-5(4H)-one, 260 mg (1.29 mmol) 4-tert-butyl-cyclohexanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

Workup

  1. customThe crude product is used in the next step without further purification

Sources & evidence

ORD record
ord-f368bb1ba1b14e9baf92394e9f754c20
Source dataset
uspto-grants-2006_10
Patent number
US07115602B2

Reaction notes

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