Magnesium → HCID 178521033, compound

Participants

Reaction Steps

To a stirring solution of: trans-toluene-4-sulfonic acid 3-(4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutylmethyl ester (example 48) (0.5 g, 1.2 mmol) in methyl alcohol (12.5 mL) was added magnesium turning. After 16 hours the reaction turned from a colorless solutions to a milky white solution. The reaction was quenched by the addtion of 1 mL of an aqueous solution of 15% NaOH and water. The solids were filtered off through a plug of celiteand the aqueous layer was extracted with 3:1 CH3Cl:isopropyl alcohol. The combined organic layer were dried over MgSO4, filtered through a fritted funnel and concentrated under reduced pressure to yield the title compound (242 mg, 79% yield) as a colorless oil. This material was processed without further purification.

Provenance & Evidence