Hydroxyamine hydrochloride → HCID 178513266, compound

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of Example 222 (4-(3-Pyrrolidin-1-ylmethyl-cyclobutyl)-benzonitrile) (150 mg, 0.62 mmol) in MeOH (1.5 mL) was added NaHCO3 (58 mg, 0.62 mmol), followed by hydroxylamine hydrochloride (43.4 mg, 0.62 mmol). The reaction was then heated to 70° C. over night. Both TLC and MS analysis indicated complete consumption of starting material. The reaction was cooled to room temperature and concentrated under reduced pressure. Water was added and a gummy solid formed. The water was removed and the residual was taken up in MeOH and concentrated under reduced pressure to yield the title compound (50 mg, 29% yield). This material was used without further purification.

Provenance & Evidence