Trifluoroacetic acid → HCID 11527791, compound

Participants

Reaction Steps

To tert-butyl 4-({(2R,3S)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-ethyl)-1-[2-[(4-nitrobenzyl)oxy]-2-oxo-1-(triphenylphosphoranylidene)ethyl]-4-oxo-2-azetidinyl}acetyl)benzoate (2.703 g, 3.00 mmol) obtained in Step a) was added trifluoroacetic acid (9 ml) under ice-cooling and dissolved it, and the mixture was further stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure, and the residue was dissolved again in chloroform/toluene, and concentrated again under reduced pressure. To the residue was added hexane/diethyl ether, and the mixture was subjected to decantation (three times), and the resulting solid was collected by filtration, washed with hexane, and dried under reduced pressure to give 4-({(2R,3S)-3-[(1R)-1-hydroxyethyl]-1-[2-[(4-nitrobenzyl)oxy]-2-oxo-1-(triphenylphosphoranylidene)ethyl]-4-oxo-2-azetidinyl}acetyl)benzoic acid (2.187 g).

Provenance & Evidence