Ammonia → HCID 11672123, compound
Reaction equation
[CH2:1]([O:4][C:5]([O:7][C@@H:8]([C@H:10]1[C:13](=[O:14])[N:12]([C:15](=[P:22]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:16]([O:18][CH2:19][CH:20]=[CH2:21])=[O:17])[C@@H:11]1[CH2:41][C:42]([C:44]1[CH:45]=[C:46]([CH:50]=[CH:51][CH:52]=1)[C:47]([OH:49])=O)=[O:43])[CH3:9])=[O:6])[CH:2]=[CH2:3].[NH3:53]>>[CH2:1]([O:4][C:5]([O:7][C@@H:8]([C@H:10]1[C:13](=[O:14])[N:12]([C:15](=[P:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:16]([O:18][CH2:19][CH:20]=[CH2:21])=[O:17])[C@@H:11]1[CH2:41][C:42]([C:44]1[CH:52]=[CH:51][CH:50]=[C:46]([C:47]([NH2:53])=[O:49])[CH:45]=1)=[O:43])[CH3:9])=[O:6])[CH:2]=[CH2:3]Participants
3
Procedure
Allyl ((2R,3S)-3-((1R)-1-{[(allyloxy)carbonyl]oxy}ethyl)-2-{2-[3-(aminocarbonyl)phenyl]-2-oxoethyl}-4-oxo-1-azetidinyl)(triphenylphosphoranylidene)acetate (324 mg) was obtained from a half amount of 3-({(2R,3S)-3-((1R)-1-{[(allyloxy)carbonyl]oxy}ethyl)-1-[2-(allyloxy)-2-oxo-1-(triphenylphosphoranylidene)ethyl]-4-oxo-2-azetidinyl}acetyl)benzoic acid obtained in Step e) and a 28% aqueous ammonia solution in a similar manner to Reference Example 2-c).
Sources & evidence
- ORD record
- ord-4cc4240340e94680a4fb8798264284a4
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07115595B2
Reaction notes
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