Water → HCID 10000127, compound

Participants

Reaction Steps

To a stirred solution of compound 269 (500 mg; 1.3 mmol) in methanol (50 ml) was added NaBH4 (350 mg; 9.2 mmol) in small portions for a period of 10 min. After 1 hour on stirring at room temperature, water (20 ml) and a solution 10% potassium carbonate (30 ml) were added. The mixture was extracted with ethyl acetate (3×60 ml) and the organic layer was washed with brine, dried over magnesium sulfate and the solvent was removed under reduced pressure giving colorless microcrystals which correspond to the titled compound (490 mg; 97%) m.p.=248–250° C.

Provenance & Evidence