1H-indole-6-carboxylic acid → HCID 21060589, compound

HRID 1241547Notes

Reaction equation

HRID 1241547 reaction equation
Cl.Cl.Cl.[N:4]1[CH:9]=[CH:8][C:7]([CH2:10][C@H:11]([C:13]([N:15]2[CH2:20][CH2:19][CH:18]([CH:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)[CH2:17][CH2:16]2)=[O:14])[NH2:12])=[CH:6][CH:5]=1.[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37](O)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1>>[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37]([NH:12][C@@H:11]([C:13]([N:15]3[CH2:16][CH2:17][CH:18]([CH:21]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]4)[CH2:19][CH2:20]3)=[O:14])[CH2:10][C:7]3[CH:6]=[CH:5][N:4]=[CH:9][CH:8]=3)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060510HCID 21060510, compound

Product 1

HCID 21060589HCID 21060589, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(4-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperidine trihydrochloride and indole-6-carboxylic acid (23%).

Sources & evidence

ORD record
ord-5c1bc2770c5d43d7ae21bd04f37ab3f8
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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