1H-indole-6-carboxylic acid → HCID 21060583, compound

HRID 1241548Notes

Reaction equation

HRID 1241548 reaction equation
Cl.Cl.Cl.[N:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C@H:11]([C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)[CH2:17][CH2:16]1)=[O:14])[NH2:12].[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37](O)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1>>[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37]([NH:12][C@@H:11]([C:13]([N:15]3[CH2:16][CH2:17][CH:18]([CH:21]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]4)[CH2:19][CH2:20]3)=[O:14])[CH2:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][N:4]=3)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060504HCID 21060504, compound

Product 1

HCID 21060583HCID 21060583, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the subtitled compound was prepared from 1-[β-(2-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperidine trihydrochloride and indole-6-carboxylic acid (32%).

Sources & evidence

ORD record
ord-4ba97548256b49dfa944de751930dc6b
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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