1H-indole-6-carboxylic acid → HCID 21060577, compound

HRID 1241549Notes

Reaction equation

HRID 1241549 reaction equation
Cl.Cl.Cl.[CH3:4][N:5]1[CH:27]=[N:26][C:7]([CH2:8][C@H:9]([C:11]([N:13]2[CH2:18][CH2:17][CH:16]([CH:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)[CH2:15][CH2:14]2)=[O:12])[NH2:10])=[CH:6]1.[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37](O)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1>>[NH:28]1[C:36]2[C:31](=[CH:32][CH:33]=[C:34]([C:37]([NH:10][C@@H:9]([C:11]([N:13]3[CH2:18][CH2:17][CH:16]([CH:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)[CH2:15][CH2:14]3)=[O:12])[CH2:8][C:7]3[N:26]=[CH:27][N:5]([CH3:4])[CH:6]=3)=[O:38])[CH:35]=2)[CH:30]=[CH:29]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060498HCID 21060498, compound

Product 1

HCID 21060577HCID 21060577, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the subtitled compound was prepared from 1-(1-methyl-D-histidinyl)-4-(1-methylpiperidin-4-yl)piperidine trihydrochloride and indole-6-carboxylic acid (23%).

Sources & evidence

ORD record
ord-9e5d9ff0819b4da18c49c56d781aeb14
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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