1H-indole-6-carboxylic acid → HCID 21060597, compound

HRID 1241550Notes

Reaction equation

HRID 1241550 reaction equation
Cl.Cl.[CH:3]1([CH2:9][C@H:10]([C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[O:13])[NH2:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[NH:27]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([C:36](O)=[O:37])[CH:34]=2)[CH:29]=[CH:28]1>>[NH:27]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([C:36]([NH:11][C@@H:10]([C:12]([N:14]3[CH2:15][CH2:16][CH:17]([CH:20]4[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]4)[CH2:18][CH2:19]3)=[O:13])[CH2:9][CH:3]3[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]3)=[O:37])[CH:34]=2)[CH:29]=[CH:28]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060514HCID 21060514, compound

Product 1

HCID 21060597HCID 21060597, compound

Procedure

Using methods substantially equivalent to that described in Method D-1, the titled compound was prepared from 1-(β-cyclohexyl-D-alanyl)-4-(1-methylpiperidin-4-yl)piperidine dihydrochloride and indole-6-carboxylic acid (65%).

Sources & evidence

ORD record
ord-7bca699ba35748268eb892ca59da1d04
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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