1H-indole-6-carboxylic acid → HCID 21060587, compound

HRID 1241551Notes

Reaction equation

HRID 1241551 reaction equation
Cl.Cl.Cl.Cl.[N:5]1[CH:10]=[CH:9][C:8]([CH2:11][C@H:12]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[O:15])[NH2:13])=[CH:7][CH:6]=1.[NH:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38](O)=[O:39])[CH:36]=2)[CH:31]=[CH:30]1>>[NH:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38]([NH:13][C@@H:12]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH:22]4[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]4)[CH2:18][CH2:17]3)=[O:15])[CH2:11][C:8]3[CH:7]=[CH:6][N:5]=[CH:10][CH:9]=3)=[O:39])[CH:36]=2)[CH:31]=[CH:30]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060508HCID 21060508, compound

Product 1

HCID 21060587HCID 21060587, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(4-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperazine tetrahydrochloride and indole-6-carboxylic acid (50%).

Sources & evidence

ORD record
ord-9c3073b431e446ceb346923b6352b6de
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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