6-Chloro-1-benzothiophene-2-carboxylic acid → HCID 21060555, compound

HRID 1241552Notes

Reaction equation

HRID 1241552 reaction equation
Cl.Cl.Cl.Cl.[N:5]1[CH:10]=[CH:9][C:8]([CH2:11][C@H:12]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[O:15])[NH2:13])=[CH:7][CH:6]=1.[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[CH:37]=[C:36]([C:38](O)=[O:39])[S:35][C:34]=2[CH:41]=1>>[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[CH:37]=[C:36]([C:38]([NH:13][C@@H:12]([C:14]([N:16]3[CH2:21][CH2:20][N:19]([CH:22]4[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]4)[CH2:18][CH2:17]3)=[O:15])[CH2:11][C:8]3[CH:7]=[CH:6][N:5]=[CH:10][CH:9]=3)=[O:39])[S:35][C:34]=2[CH:41]=1

Participants

3

Reactant 2

HCID 71419196-Chloro-1-benzothiophene-2-carboxylic acidHCID 21060508HCID 21060508, compound

Product 1

HCID 21060555HCID 21060555, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(4-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperazine tetrahydrochloride and 6-chlorobenzo[b]thiophene-2-carboxylic acid (49%).

Sources & evidence

ORD record
ord-f1b4af1b5e0f47acb7305357db93ff94
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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