5-Chloro-1H-indole-2-carboxylic acid → HCID 21060537, compound

HRID 1241553Notes

Reaction equation

HRID 1241553 reaction equation
Cl.Cl.Cl.Cl.[N:5]1[CH:10]=[CH:9][C:8]([CH2:11][C@H:12]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[O:15])[NH2:13])=[CH:7][CH:6]=1.[Cl:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:39](O)=[O:40])=[CH:33]2>>[Cl:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:39]([NH:13][C@@H:12]([C:14]([N:16]1[CH2:21][CH2:20][N:19]([CH:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[CH2:18][CH2:17]1)=[O:15])[CH2:11][C:8]1[CH:7]=[CH:6][N:5]=[CH:10][CH:9]=1)=[O:40])=[CH:33]2

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21060508HCID 21060508, compound

Product 1

HCID 21060537HCID 21060537, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(4-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperazine tetrahydrochloride and 5-chloroindole-2-carboxylic acid (47%).

Sources & evidence

ORD record
ord-a95b35146ab142d5bbe2ccecafe27739
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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