1H-indole-6-carboxylic acid → HCID 21060581, compound

HRID 1241555Notes

Reaction equation

HRID 1241555 reaction equation
Cl.Cl.Cl.Cl.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][C@H:12]([C:14]([N:16]1[CH2:21][CH2:20][N:19]([CH:22]2[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]2)[CH2:18][CH2:17]1)=[O:15])[NH2:13].[NH:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38](O)=[O:39])[CH:36]=2)[CH:31]=[CH:30]1>>[NH:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([C:38]([NH:13][C@@H:12]([C:14]([N:16]3[CH2:17][CH2:18][N:19]([CH:22]4[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]4)[CH2:20][CH2:21]3)=[O:15])[CH2:11][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][N:5]=3)=[O:39])[CH:36]=2)[CH:31]=[CH:30]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060502HCID 21060502, compound

Product 1

HCID 21060581HCID 21060581, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(2-pyridinyl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperazine tetrahydrochloride and indole-6-carboxylic acid (62%).

Sources & evidence

ORD record
ord-84643dd004b94a39991b6fead61dd13c
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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