1H-indole-6-carboxylic acid → HCID 21060603, compound

HRID 1241557Notes

Reaction equation

HRID 1241557 reaction equation
Cl.Cl.Cl.[NH2:4][C@@H:5]([C:11]([N:13]1[CH2:18][CH2:17][N:16]([CH:19]2[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]2)[CH2:15][CH2:14]1)=[O:12])[CH2:6][CH2:7][C:8](=[O:10])[OH:9].[NH:26]1[C:34]2[C:29](=[CH:30][CH:31]=[C:32]([C:35](O)=[O:36])[CH:33]=2)[CH:28]=[CH:27]1>>[NH:26]1[C:34]2[C:29](=[CH:30][CH:31]=[C:32]([C:35]([NH:4][C@@H:5]([C:11]([N:13]3[CH2:14][CH2:15][N:16]([CH:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)[CH2:17][CH2:18]3)=[O:12])[CH2:6][CH2:7][C:8](=[O:9])[OH:10])=[O:36])[CH:33]=2)[CH:28]=[CH:27]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 21060517HCID 21060517, compound

Product 1

HCID 21060603HCID 21060603, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-(D-glutamyl)-4-(1-methylpiperidin-4-yl)piperazine trihydrochloride and indole-6-carboxylic acid (46%).

Sources & evidence

ORD record
ord-b4f054be344542368cb04c7afd834977
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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