5-Chloro-1H-indole-2-carboxylic acid → HCID 21060545, compound

HRID 1241559Notes

Reaction equation

HRID 1241559 reaction equation
Cl.Cl.Cl.[NH2:4][C@@H:5]([C:11]([N:13]1[CH2:18][CH2:17][N:16]([CH:19]2[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]2)[CH2:15][CH2:14]1)=[O:12])[CH2:6][CH2:7][C:8](=[O:10])[OH:9].[Cl:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][C:31]([C:36](O)=[O:37])=[CH:30]2>>[Cl:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][CH:35]=1)[NH:32][C:31]([C:36]([NH:4][C@@H:5]([C:11]([N:13]1[CH2:14][CH2:15][N:16]([CH:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)[CH2:17][CH2:18]1)=[O:12])[CH2:6][CH2:7][C:8](=[O:9])[OH:10])=[O:37])=[CH:30]2

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21060517HCID 21060517, compound

Product 1

HCID 21060545HCID 21060545, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-(D-glutamyl)-4-(1-methylpiperidin-4-yl)piperazine trihydrochloride and 5-chloroindole-2-carboxylic acid (43%).

Sources & evidence

ORD record
ord-144b53524bc649129bca91360c4ec041
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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