5-Chloro-1H-indole-2-carboxylic acid → HCID 21060533, compound

HRID 1241562Notes

Reaction equation

HRID 1241562 reaction equation
Cl.Cl.Cl.Cl.[CH3:5][N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C@H:13]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([CH:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)[CH2:19][CH2:18]2)=[O:16])[NH2:14])[CH2:8][CH2:7]1.[Cl:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][C:35]([C:40](O)=[O:41])=[CH:34]2>>[Cl:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][C:35]([C:40]([NH:14][C@@H:13]([C:15]([N:17]1[CH2:18][CH2:19][N:20]([CH:23]3[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]3)[CH2:21][CH2:22]1)=[O:16])[CH2:12][CH:9]1[CH2:10][CH2:11][N:6]([CH3:5])[CH2:7][CH2:8]1)=[O:41])=[CH:34]2

Participants

3

Reactant 2

HCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 21060500HCID 21060500, compound

Product 1

HCID 21060533HCID 21060533, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-[β-(1-methylpiperidin-4-yl)-D-alanyl]-4-(1-methylpiperidin-4-yl)piperazine tetrahydrochloride and 5-chloroindole-2-carboxylic acid (46%).

Sources & evidence

ORD record
ord-40850c510163481386e5bbd6b7979749
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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