1H-indole-6-carboxylic acid → HCID 67550321, compound

HRID 1241563Notes

Reaction equation

HRID 1241563 reaction equation
Cl.Cl.Cl.[NH2:4][C@@H:5]([C:10]([N:12]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]2)[CH2:14][CH2:13]1)=[O:11])[CH2:6][C:7](=[O:9])[NH2:8].[NH:25]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([C:34](O)=[O:35])[CH:32]=2)[CH:27]=[CH:26]1>>[NH:25]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([C:34]([NH:4][C@@H:5]([C:10]([N:12]3[CH2:17][CH2:16][N:15]([CH:18]4[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]4)[CH2:14][CH2:13]3)=[O:11])[CH2:6][C:7](=[O:9])[NH2:8])=[O:35])[CH:32]=2)[CH:27]=[CH:26]1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 69597341HCID 69597341, compound

Product 1

HCID 67550321HCID 67550321, compound

Procedure

Using methods substantially equivalent to those described in Method D-1, the titled compound was prepared from 1-(D-asparaginyl)-4-(1-methylpiperidin-4-yl)piperazine trihydrochloride and indole-6-carboxylic acid (45%).

Sources & evidence

ORD record
ord-336df4a544a4475fb59d1c061bc777a4
Source dataset
uspto-grants-2006_10
Patent number
US07115609B2

Reaction notes

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