Maleic Acid → HCID 131725962, compound

Participants

Reaction Steps

A solution of maleic acid (0.58 g, 1 equiv) in methanol (10 ml) was added to a solution of the free base from Example 6 (3.43 g, 1 equiv) in methanol (10 ml) with stirring. The mixture was evaporated to ca. half volume, diluted with ether, then the supernatent decanted off. The oil was triturated with ether to obtain a solid, which was filtered off, washed with ether and dried in vacuo; yield 3.69 g. 1H-NMR (DMSO, ca. 3:1 rotamer mixture) essentially similar to Example 7, plus δ 2.33 (3H,s); MS (APCI+) found (M+1)=687/689; C37H40ClFN6O2S requires 686/688.

Provenance & Evidence