Hydrochloric Acid → HCID 69592660, compound

Participants

Reaction Steps

The free base from Example 17 (0.373 g, 1 equiv) was dissolved in dichloromethane (10 ml), and a solution of hydrogen chloride in ether (0.517 ml, 1.0M solution, 1 equiv) was added dropwise with stirring. The solvent was removed in vacuo, and the residue triturated with ether to obtain a white solid (0.362 g). 1H-NMR (DMSO, ca. 60:40 rotamer mixture) δ 1.1–1.3 (6H,m), 3.77 (3H,s), 4.38/4.43 (2H,s), 4.65/4.76 (2H,s), 5.00/5.08 (2H,s), 7.10 (2H,m), 7.25 (1H,m), 7.3–7.5 (4H,m) 7.78 (1H,m), 7.87 (2H,d), 7.97/8.06 (1H,d), 8.28 (2H,d), 8.61/8.70 (1H,m); MS (APCI+) found (M+1)=722; C37H39F4N7O2S requires 721.

Provenance & Evidence