4-Bromophenyl isothiocyanate → HCID 21936576, compound

Participants

Reaction Steps

To a solution of 4-bromophenyl isothiocyanate (1.50 g, 7.01 mmol) in THF (30 mL) at room temperature was added (±) 3,3-dimethyl-2-aminobutane (1.41 mL, 10.5 mmol) and the reaction was stirred overnight at room temperature. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 1.76 g (80%) of 1-(4-bromophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea as a white solid which was used without further purification.

Provenance & Evidence