Neopentylamine → N'-(2,2-Dimethylpropyl)-N-pyridin-3-ylcarbamimidothioic acid

Participants

Reaction Steps

To a solution of 3-pyridyl-isothiocyanate (1.50 mL, 13.3 mmol) in THF (30 mL) at room temperature was added neopentylamine (2.35 mL, 19.8 mmol) and the reaction was stirred overnight at room temperature. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 2.64 g (89%) of 1-(3-pyridyl)-3-(2,2-dimethylpropyl)-thiourea as an off-white solid which was used without further purification.

Provenance & Evidence