Dimethyl Sulfate → HCID 21936556, compound

HRID 1241688Notes

Reaction equation

HRID 1241688 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.[CH3:13][O:14][S:15]([O:18]C)(=[O:17])=[O:16]>>[CH3:13][O:14][S:15]([O-:18])(=[O:17])=[O:16].[CH3:13][N+:8]1[C:9]2[C:4](=[CH:3][C:2]([F:1])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:12]

Participants

3

Reactant 2

HCID 6497Dimethyl SulfateHCID 707846-Fluoro-2-methylquinoline2×

Product 1

HCID 21936556HCID 21936556, compoundYield 86%

Procedure

6-Fluoro-2-methylquinoline, 4 (25 g, 0.15 mol) was alkylated with dimethylsulphate (1.89 g, 0.15 mmol) as above to give the title compound (37.5 g, 0.13 mol, 86%).

Sources & evidence

ORD record
ord-62411f6a59f7479db776cafdb558cec7
Source dataset
uspto-grants-2006_10
Patent number
US07115619B2

Reaction notes

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