p-Toluenesulfonic acid → HCID 5496199, compound

Participants

Reaction Steps

(Method E-5) 2-Amino-4-chlorobenzoate (50 g, 0.27 mol), dry phlorglucinol (40 g, 0.32 mol), hexanol (120 ml), and p-toluene sulphonic acid (1.6 g, 9 mmol) were mixed and heated to reflux with Dean-Stark removal of water for 2 hrs. On cooling petroleum ether (2 L) was slowly added and the solid was filtered off, washed with petroleum ether and dichloromethane to give the title compound (58.8 g, 0.22 mmol, 83.4%).

Provenance & Evidence