Aluminum(III) Chloride → HCID 178479883, compound

HRID 1241699Notes

Reaction equation

HRID 1241699 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:25]=[C:24]4[C:19]([CH:20]=[CH:21][CH:22]=[CH:23]4)=[C:8]4[CH:9]=[C:10]([O:17]C)[CH:11]=[C:12]([N:13]([CH3:16])[C:14]=2[CH:15]=1)[C:7]=34.ClC1C=CC2C3N=C4C(C=CC=C4)=C4C=C(OC)C=C(NC=2C=1)C=34.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:25]=[C:24]4[C:19]([CH:20]=[CH:21][CH:22]=[CH:23]4)=[C:8]4[CH:9]=[C:10]([OH:17])[CH:11]=[C:12]([N:13]([CH3:16])[C:14]=2[CH:15]=1)[C:7]=34

Participants

5

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 11110795HCID 11110795, compoundHCID 21936572HCID 21936572, compound

Product 1

HCID 178479883HCID 178479883, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The general procedure (Method K) applied to 10-chloro-6-methoxy-8-methyl-8H-quino[4,3,2-kl]acridine, 33 (2.6 g, 7.5 mmol), with aluminium chloride (3.2 g, 3 eq), and benzene (500 ml) gave the title compound a yellow solid (2.43 g, 7.3 mmol, 98%).

Sources & evidence

ORD record
ord-8d97e5e0cf3041b293ac47aae2e51cd8
Source dataset
uspto-grants-2006_10
Patent number
US07115619B2

Reaction notes

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