HCID 11132296, compound → HCID 21060843, compound

Participants

Reaction Steps

(Method N) (E)-3-(8-Methyl-8H-quino[4,3,2-kl]acridin-3-yl)-acrylic acid methyl ester, 40 (50 mg, 0.14 mmol) was suspended in ethyl acetate (150 mL) and shaken under pressure of hydrogen (40 psi) with 10% palladium on carbon (100 mg) for 2 days. The mixture was filtered through celite, the solvent evaporated under reduced pressure, the product adsorbed onto silica and purified by column chromatography (1:4 EtOAc:hexane) to give the title compound (36 mg, 0.098 mmol, 70%).

Provenance & Evidence