Dicyclohexylamine → HCID 10983514, compound

Participants

Reaction Steps

(Method P) Under an atmosphere of nitrogen, trifluoromethanesulphonic acid 3-chloro-8-methyl-8H-quino[4,3,2-kl]acridin-6-yl ester, 38 (30 mg, 0.075 mmol), allyltrifluoroacetamide (17 mg, 1.5 eq), palladium (II) acetate (2 mg, 10 mol %), triphenyl phosphine (4 mg, 20 mol %), dicyclohexylamine (0.032 mL, 2 eq), and dioxane were mixed in a sealed tube and heated reflux in a sealed tube for 18 hrs. On cooling, the products were dissolved in dichloromethane and adsorbed onto silica. Separation of the more polar product by column chromatography (85:15 hexane:ethyl acetate) gave the title compound (22 mg, 0.045 mmol, 60%).

Provenance & Evidence