Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 10925151 | HCID 10925151 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 11266792 | HCID 11266792 | 99% |
Reaction Steps
(Method T) 3-Chloro-8-methyl-8H-quino[4,3,2-kl]acridine, 28 (150 mg, 0.47 mmol), tris(dibenzylideneacetone)dipalladium (0) (9 mg), bisdiphenylphosphino ferrocene (17 mg), zinc powder (5 mg), zinc cyanide (33 mg) and DMA were mixed in a sealed tube, flushed with nitrogen, the tube sealed and the mixture heated to 100° C. for 3 days. The cooled mixture was taken up in dichloromethane (50 mL), washed with 2M ammonium hydroxide (20 mL) and water (20 mL), dried, filtered, evaporated and purified by column chromatography to the title compound (147 mg, 0.46 mmol, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07115619B2 |
|---|
| Source dataset | uspto-grants-2006_10 |
|---|
| ORD ID | ord-beb9567c109d4541ace006cf3c7a2537 |
|---|
| Source note | uspto-grants-2006_10 |
|---|
