HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 21936622, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-(3-Nitro-phenylamino)-pyridine-3-carbaldehyde | HCID 12114952 | — |
| Reactant | HCID 21936624 | HCID 21936624 | — |
| Product | HCID 21936622 | HCID 21936622 | 4.9% |
Reaction Steps
The procedure of Example 1 was repeated using 2-(3-nitrophenylamino)nicotinaldehyde (1.0 eq.), ethyl 5-(pyridazin-3-yl)pentanoate (1.2 eq., prepared in Synthetic Example 6) and LDA (1.2 eq.) to obtain 1-(3-nitrophenyl)-3-[3-(pyridazin-3-yl)propyl]-1,8-naphthyridin-2(1H)-one (yield, 4.9%). The product was purified through flash column chromatography and recrystallization (mp 234–235° C./DMF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115623B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-faa712e372fe429a94b3fd4d817f0799 |
| Source note | uspto-grants-2006_10 |