HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 21936614, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-(3-Nitro-phenylamino)-pyridine-3-carbaldehyde | HCID 12114952 | — |
| Reactant | HCID 21936619 | HCID 21936619 | — |
| Product | HCID 21936614 | HCID 21936614 | 33% |
Reaction Steps
The procedure of Example 1 was repeated using 2-(3-nitrophenylamino)nicotinaldehyde (1.0 eq.), ethyl 5-(pyrazin-2-yl)pentanoate (1.5 eq., prepared in Synthetic Example 7) and LDA (1.5 eq.) to obtain 1-(3-nitrophenyl)-3-[3-(pyrazin-2-yl)propyl]-1,8-naphthyridin-2(1H)-one (yield, 33%). The product was purified through flash column chromatography and recrystallization (mp 194–195° C./DMF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115623B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ec3507fc9d194102ae946f9cfaf4f9b5 |
| Source note | uspto-grants-2006_10 |