HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 9843930, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 2-(3-Nitro-phenylamino)-pyridine-3-carbaldehyde | HCID 12114952 | — |
| Reactant | HCID 21936633 | HCID 21936633 | — |
| Product | HCID 9843930 | HCID 9843930 | 37% |
Reaction Steps
The procedure of Example 1 was repeated using 2-(3-nitrophenylamino)nicotinaldehyde (1.0 eq.), ethyl 5-methyl-5-(pyridin-4-yl)pentanoate (1.5 eq.; prepared in Synthetic Example 8) and LDA(1.5 eq.) to obtain 1-(3-nitrophenyl)-3-[3-methyl-3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (yield, 37%). The product was purified through flash column chromatography and recrystallization (mp 154–155° C./DMF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07115623B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-8be01486a6564a73b2ec5cc5139026c2 |
| Source note | uspto-grants-2006_10 |