Acetic Anhydride → HCID 21936635, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3-nitrophenyl)-3-[3-hydroxy-3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (50 mg, 0.12 mmol; prepared in Example 20) in acetic anhydride (0.2 ml) and pyridine (0.3 ml) was heated at 100° C. for 20 min, concentrated, and extracted with chloroform. The extract was treated according to conventional techniques, concentrated, and then purified by flash column chromatography to afford 1-(3-nitrophenyl)-3-[3-acetyloxy-3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (55.2 mg, 100%; mp 69–71° C.).

Provenance & Evidence