HCID 21933863, compound → 2-(3,4-Difluorophenyl)-4-methoxy-5-[3-methyl-4-(methylthio)phenyl]-3(2H)-pyridazinone

Participants

Reaction Steps

The title compound was prepared according to the method of Example 6 starting with 2-(3,4-difluorophenyl)-4-methoxy-5-bromo-3(2H)-pyridazinone in place of 2-benzyl-4-bromo-5-methoxy-3(2H)-pyridazinone and substituting 3-methyl-4-(methylthio)benzeneboronic acid in place of 4-fluorobenzeneboronic acid (yield: 2.0 g, 85%). 1H NMR (300 MHz, CDCl3) δ 2.39 (s, 3H), 2.53 (s, 3H), 4.11 (s, 3H), 7.22–7,32 (m, 2H), 7.34 (s, 1H), 7.42–7.50 (m, 2H), 7.55–7.64 (m, 1H), 7.92 (s, 1H). MS (APCI+) m/z 375 (M+H)+.

Provenance & Evidence