Acetic Acid → t-butyl (1S)-2-(1H-benzimidazol-1-yl)-1-[(3-methylphenoxy)methyl]ethylcarbamate

Participants

Reaction Conditions

Reaction Steps

To the compound (85 mg) obtained in Step 2 were added methyl orthformate (1 ml) and acetic acid (50 μl), and the mixture was stirred at 60° C. for 1 hr. The mixture was diluted with ethyl acetate, and washed with 1N sodium hydroxide. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated. The obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give the title compound (60 mg).

Provenance & Evidence