Ammonia → 2-(3,4-Difluorophenyl)-4-(4-fluorophenoxy)-5-[4-(aminosulfonyl)phenyl]-3(2H)-pyridazinone

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-(3,4-Difluorophenyl)-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone	HCID 10096332	—
Solvent	Water	HCID 962	—
Product	2-(3,4-Difluorophenyl)-4-(4-fluorophenoxy)-5-[4-(aminosulfonyl)phenyl]-3(2H)-pyridazinone	HCID 21934166	—

Reaction Steps

The product from Example 109 was converted to the title sulfonamide according to the method of Example 384 (yield: 110 mg, 45.7%). mp 224–226° C. 1H NMR (300 MHz, CDCl3) δ 4.86 (br s, 2H), 6.89–7.03 (m, 4H), 7.19–7.30 (m, 1H), 7.45–7.52 (m, 1H), 7.56–7.66 (m, 1H), 7.79 (d, J=9 Hz, 2H), 8.04 (d, J=9 Hz, 1H), 8.08 (s, 1H). MS (DCI/NH3) m/z 474 (M+H)+, 491 (M+NH4)+. Anal. calc. for C22H14F3N3O4S.0.25 H2O: C, 55.32; H, 2.93; N, 8.80. Found: C, 55.26; H, 3.11; N, 8.58.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07115591B2
Source dataset	uspto-grants-2006_10
ORD ID	ord-1695e5b112494063996ea3bdcd642dbc
Source note	uspto-grants-2006_10