Ammonia → HCID 10138015, compound

Participants

Reaction Steps

The title compound was prepared as described in Example 62, substituting 4-(3-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone (yield: 135 mg, 34%). mp 199–201° C. 1H NMR (300 MHz, DMSO-d6) δ 3.24 (s, 3H), 6.98 (d, J=9 Hz, 1H), 7.18 (m, 2H), 7.32 (m, 1H), 7.39 (t, 1H), 7.54 (d, J=9 Hz, 2 H), 7.71 (m, 2H), 7.91 (d, J=9 Hz, 2 H), 8.27 (s, 1 H). MS (DCI/NH3) m/z 439 (M+H)+, 456 (M+NH4)+.

Provenance & Evidence