Cyclohexylmethyl-(2-nitro-4-phenoxy-phenyl)-amine → N1-cyclohexylmethyl-4-phenoxy-benzene-1,2-diamine

Beteiligte Stoffe

Reaktionsschritte

To a solution of cyclohexylmethyl-(2-nitro-4-phenoxy-phenyl)-amine (0.55 g, 1.69 mmol) in THF (50 mL) was added palladium, 10% on activated carbon (0.55 g). The reaction flask was equipped with a septum and was placed under vacuum for 3 min. This flask was placed under hydrogen atmosphere (balloon inflated with hydrogen) and the reaction mixture was stirred for 18 h. The palladium was filtered off through a plug of diatomaceous earth and washed with EtOAc. The solvent was removed via rotary evaporation providing N1-cyclohexylmethyl-4-phenoxy-benzene-1,2-diamine (0.50 g, 99% yield) which was used in the next step without further purification.

Herkunft & Nachweise