Dimethylformamide → HCID 73855062, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product of Example 57 in DMF were added K2CO3 and 3-bromoethanol and the resulting suspension was heated to 75° C. with stirring under nitrogen for 72 h. Solid was removed by filtration and washed by DMF. Evaporation of solvent gave a crude, which was purified by chromatography on silica gel eluting with MeOH-DCM (5:95) to afford the title compound (0.58 g). 1H-NMR indicated one isomer. 1H-NMR (DMSO-d6): δ 7.62 (1H, d), 7.29–7.39 (5H, m), 7.14 (1H, d), 7.02 (1H, d), 6.84 (1H, dd), 5.75 (1H, d), 5.11 (2H, s), 4.97 (1H, t), 4.87(1H, t), 4.05 (2H, t), 3.80 (3H, s), 3.71 (2H, m), 3.05 (2H, m), 0.99 (3H, t); MS (ESI): 558 (MH+).

Provenance & Evidence