Ethylamine → HCID 21937437, compound

Participants

Reaction Conditions

Reaction Steps

To a pressure tube was added 4-fluoro-3-nitroaniline (550 mg, 3.50 mmol) and a 2.0 M solution of ethylamine in THF (8 mL). The sealed tube was heated at 120° C. for 24 h. The reaction solution was cooled, diluted with EtOAc (30 mL), washed with saturated NaHCO3 (2×25 mL), dried over Na2SO4, and concentrated under reduced pressure to provide the title compound (625 mg, 98%) as a purple solid. 1H-NMR (CDCl3): δ 7.72 (1H, br s), 7.49 (1H, d), 6.96 (1H, dd), 6.74 (1H, d), 3.45 (2H, br s), 3.30 (2H, m), 1.33 (3H, t).

Provenance & Evidence